Cloned (Comment) | Organism |
---|---|
DNA sequence determination, genomic structure | Mus musculus |
DNA sequence determination, genomic structure | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cd2+ | brain enzyme, strong inhibition | Bos taurus | |
Cd2+ | brain enzyme, strong inhibition | Homo sapiens | |
Cd2+ | brain enzyme, strong inhibition | Ovis aries |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.004 | - |
NADPH | erythrocyte enzyme, pH 7.0, 30°C | Bos taurus | |
0.005 | - |
NADPH | liver enzyme, pH 7.0, 30°C | Bos taurus | |
0.008 | - |
NADPH | liver enzyme | Rattus norvegicus | |
0.008 | - |
NADPH | brain enzyme, pH 7.0, 30°C | Bos taurus | |
0.009 | - |
NADPH | - |
Homo sapiens | |
0.009 | - |
NADPH | liver enzyme | Equus caballus | |
0.009 | - |
NADPH | erythrocyte enzyme | Oryctolagus cuniculus | |
0.021 | - |
NADPH | calf liver enzyme, pH 7.0, 30°C | Bos taurus | |
0.023 | - |
glutathione | erythrocyte enzyme, pH 7.0, 30°C | Bos taurus | |
0.036 | - |
glutathione | brain enzyme, pH 7.0, 30°C | Bos taurus | |
0.04 | - |
glutathione | liver enzyme, pH 7.0, 30°C | Bos taurus | |
0.057 | - |
glutathione | liver enzyme | Rattus norvegicus | |
0.059 | - |
glutathione | liver enzyme | Equus caballus | |
0.061 | - |
NADPH | brain enzyme | Ovis aries | |
0.065 | - |
glutathione | - |
Homo sapiens | |
0.065 | - |
glutathione | erythrocyte enzyme | Oryctolagus cuniculus | |
0.101 | - |
glutathione | calf liver enzyme, pH 7.0, 30°C | Bos taurus | |
0.117 | - |
glutathione | brain enzyme | Ovis aries |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
51698 | - |
2 * 51698, sequence calculation | Homo sapiens |
52000 | - |
bovine erythrocyte enzyme, gel fitration | Bos taurus |
55000 | - |
bovine brain enzyme, gel fitration | Bos taurus |
60000 | - |
about | Rattus norvegicus |
64000 | - |
about | Ovis aries |
67000 | - |
liver enzyme, about | Oryctolagus cuniculus |
100000 | - |
gel filtration | Homo sapiens |
100000 | - |
calf liver enzyme, gel filtration | Bos taurus |
107000 | - |
liver enzyme, gel filtration | Equus caballus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH | Mus musculus | - |
glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | Rattus norvegicus | - |
glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | Oryctolagus cuniculus | - |
glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | Ovis aries | - |
glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | Equus caballus | - |
glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | Homo sapiens | enzyme is required for disposal of peroxides and radicals especially in the brain | glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | Bos taurus | enzyme is required for disposal of peroxides and radicals especially in the brain | glutathione + NADP+ | - |
? | |
additional information | Bos taurus | enzyme is connected to neuronal loss during progression of neurodegenerative disorders | ? | - |
? | |
additional information | Homo sapiens | enzyme is connected to neuronal loss during progression of neurodegenerative disorders like Alzheimer's or Parkinson's disease | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Equus caballus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Ovis aries | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
5000fold from brain to homogeneity in several steps, overview | Bos taurus |
from erythrocyte | Homo sapiens |
to homogeneity from brain | Ovis aries |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Homo sapiens | - |
astrocytic glioma cell | low enzyme activity | Homo sapiens | - |
brain | low enzyme content | Mus musculus | - |
brain | low enzyme content | Homo sapiens | - |
brain | low enzyme content | Bos taurus | - |
brain | low enzyme content | Ovis aries | - |
erythrocyte | - |
Homo sapiens | - |
erythrocyte | - |
Bos taurus | - |
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Bos taurus | - |
kidney | - |
Ovis aries | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Oryctolagus cuniculus | - |
liver | - |
Equus caballus | - |
liver | high enzyme content | Mus musculus | - |
liver | high enzyme content | Homo sapiens | - |
liver | high enzyme content | Bos taurus | - |
liver | high enzyme content | Ovis aries | - |
microglia | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
oligodendroglial cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.03 | - |
brain homogenate | Bos taurus |
114 | - |
purified enzyme from erythrocyte | Bos taurus |
145 | - |
purified enzyme from brain | Bos taurus |
147 | - |
purified enzyme from liver | Bos taurus |
180 | - |
purified liver enzyme | Oryctolagus cuniculus |
193 | - |
purified enzyme from brain | Ovis aries |
207 | - |
purified enzyme from liver | Rattus norvegicus |
240 | - |
purified enzyme from erythrocyte | Homo sapiens |
248 | - |
purified liver enzyme | Equus caballus |
Storage Stability | Organism |
---|---|
4°C, concentrated purified enzyme, 0.05% NaN3, 50 mM potassium phosphate, pH 7.4, 2 mM EDTA, 150 mM NaCl, 2 mM glutathione, quite stable | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH | - |
Mus musculus | glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | - |
Homo sapiens | glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | - |
Rattus norvegicus | glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | - |
Bos taurus | glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | - |
Oryctolagus cuniculus | glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | - |
Ovis aries | glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | - |
Equus caballus | glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | enzyme is required for disposal of peroxides and radicals especially in the brain | Homo sapiens | glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | enzyme is required for disposal of peroxides and radicals especially in the brain | Bos taurus | glutathione + NADP+ | - |
? | |
additional information | enzyme is connected to neuronal loss during progression of neurodegenerative disorders | Bos taurus | ? | - |
? | |
additional information | enzyme is connected to neuronal loss during progression of neurodegenerative disorders like Alzheimer's or Parkinson's disease | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | liver enzyme | Equus caballus |
dimer | 2 * 51698, sequence calculation | Homo sapiens |
dimer | 2 * 55000, calf liver enzyme, SDS-PAGE | Bos taurus |
monomer | 1 * 55000, bovine brain enzyme, SDS-PAGE, 1 * 52000, bovine erythrocyte and liver enzyme, SDS-PAGE | Bos taurus |
monomer | 1 * 60000, liver enzyme, SDS-PAGE | Rattus norvegicus |
monomer | 1 * 64000 | Ovis aries |
monomer | 1 * 67000, liver enzyme | Oryctolagus cuniculus |
More | three-dimensional structure determination | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
glutathione reductase | - |
Mus musculus |
glutathione reductase | - |
Homo sapiens |
glutathione reductase | - |
Rattus norvegicus |
glutathione reductase | - |
Bos taurus |
glutathione reductase | - |
Oryctolagus cuniculus |
glutathione reductase | - |
Ovis aries |
glutathione reductase | - |
Equus caballus |
GR | - |
Mus musculus |
GR | - |
Homo sapiens |
GR | - |
Rattus norvegicus |
GR | - |
Bos taurus |
GR | - |
Oryctolagus cuniculus |
GR | - |
Ovis aries |
GR | - |
Equus caballus |
NADPH:oxidized-glutathione oxidoreductase | - |
Mus musculus |
NADPH:oxidized-glutathione oxidoreductase | - |
Homo sapiens |
NADPH:oxidized-glutathione oxidoreductase | - |
Rattus norvegicus |
NADPH:oxidized-glutathione oxidoreductase | - |
Bos taurus |
NADPH:oxidized-glutathione oxidoreductase | - |
Oryctolagus cuniculus |
NADPH:oxidized-glutathione oxidoreductase | - |
Ovis aries |
NADPH:oxidized-glutathione oxidoreductase | - |
Equus caballus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | dependent on | Mus musculus | |
NADPH | dependent on | Homo sapiens | |
NADPH | dependent on | Rattus norvegicus | |
NADPH | dependent on | Bos taurus | |
NADPH | dependent on | Oryctolagus cuniculus | |
NADPH | dependent on | Ovis aries | |
NADPH | dependent on | Equus caballus |